Publications

2023

  • Boatman, A. K., Chappel, J. R., Polera, M. E., Dodds, J. N., Belcher, S. M., & Baker, E. S. (2023, September 5). Assessing Per- and Polyfluoroalkyl Substances (PFAS) in Fish Fillet Using Non-Targeted Analyses. (Preprint: https://doi.org/10.1101/2023.09.01.555938)
  • Cuffney, M., Wilkie, A., Kotlarz, N., Knappe, D., Lea, C., Collier, D., DeWitt J., Hoppin J. (2023, September 4). Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study. https://doi.org/10.1016/j.envres.2023.117020.
  • Efromson J, Ferrero G,  Bègu A, Doman TJJ, Dugo C, Barker A, Saliu V, Reamey P, Kim K, Harfouche M, Yoder JA. 2023. Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope. BioRxiv. 553550 [Preprint, posted August 18, 2023]. PMID: 37645798. PMCID: PMC10462042. Available from: https://doi.org/10.1101/2023.08.16.553550.
  • Phelps W, Palekar A I, Conley HE, Ferrer G, Driggers JH, Linder KE, Kullman SW, Reif DM, Sheats MK, DeWitt JC, Yoder JA. 2023. Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst. J Immunotoxicol. 20(1): 2176953. PMID: 36788734. PMCID: PMC10361455. DOI: 10.1080/1547691X.2023.2176953.
  • Taylor KD, Woodlief TL, Ahmed A, Hu Q, Duncker PC, DeWitt JC. 2023. Quantifying the impact of PFOA Exposure on B cell development and antibody production. Toxicol Sci. 194(1): 101-108. PMID: 37162486. PMCID: PMC10306397. DOI: 10.1093/toxsci/kfad043.
  • Zhang C, Tang T, Knappe DRU. 2023. Oxidation of Per- and Polyfluoroalkyl Ether Acids and Other Per- and Polyfluoroalkyl Substances by Sulfate and Hydroxyl Radicals: Kinetic Insights from Experiments and Models. Environ Sci Technol, online ahead of print. PMID: 37223990. NIHMS: NIHMS1929684. DOI: 10.1021/acs.est.3c00947.

2022

  • Belcher SM, Guillette MP, Robb F, Rock KD. 2022. Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida. Ecotoxicology. 31(7):1137-1146. PMID: 35918620. PMCID: PMC9463099. DOI: 10.1007/s10646-022-02573-z. 
  • Butler KE, Baker ES. 2022. A High-Throughput Ion Mobility Spectrometry-Mass Spectrometry Screening Method for Opioid Profiling. Journal of the American Society for Mass Spectrometry. 33(10): 1904-1913. PMID: 36136315. PMCID: PMC9616473. DOI:10.1021/jasms.2c00186.
  • Butler KE, Dodds J, Flick T, Campuzano ID, Baker ES. 2022. High-Resolution Demultiplexing (HRdm) Ion Mobility Spectrometry-Mass Spectrometry for Aspartic and Isoaspartic Acid Determination and Screening. Analytical Chemistry. 94(16): 6191-6199. PMID: 35421308. PMCID: PMC9635094.  DOI:10.1021/acs.analchem.1c05533.
  • Cohen Hubal EA, DeLuca NM, Mullikin A, Slover R, Little JC, Reif DM. 2022. Demonstrating a systems approach for integrating disparate data streams to inform decisions on children’s environmental health. BMC Public Health. 22(1):313. PMID: 35168583. PMCID: PMC8845296. DOI: 10.1186/s12889-022-12682-3.
  • Ducatman A, LaPier J, Fuoco RE, DeWitt JC. 2022. Official health communications are failing PFAS-contaminated communities. 21(1): 51. Environmental Health. PMID: 35538533. PMCID: PMC9092686. DOI: 10.1186/s12940-022-00857-9. 
  • Enders J, Weed RA, Griffith EH, Muddiman DC. 2022. Development and validation of a high resolving power absolute quantitative per- and polyfluoroalkyl substances method incorporating Skyline data processing. Rapid Communications in Mass Spectrometry. 36(11): e9295. PMID: 35275435. PMCID: PMC9287086. DOI:10.1002/rcm.9295. 
  • Evich MG, Davis MJ, McCord JP, Acrey B, Awkerman JA, Knappe DRU, Lindstrom AB, Speth TF, Tebes-Stevens C, Strynar M, Wang Z, Weber EJ, Henderson WM, Washington JW. 2022. Per- and polyfluoroalkyl substances in the environment. Science. 375(6580): eabg9065. PMID: 35113710. PMCID: PMC8902460. DOI:10.1126/science.abg9065.
  • Foster MR, Rainey M, Watson C, Dodds J, Kirkwood KI, Fernandez FM, Baker ES. 2022. Uncovering PFAS and other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning. Environmental Science & Technology. 56(12):9133-9143. PMID: 35653285. PMCID: PMC9474714. DOI:10.1021/acs.est.2c00201.
  • Guillette TC, Jackson TW, Guillette MP, Belcher SM, McCord JP. 2022. Blood Concentrations of Per- and Polyfluoroalkyl Substances are Associated with Autoimmune-like Effects in American Alligators from Wilmington, North Carolina. Front Toxicol. 4:1010185. PMID: 36227916. PMCID: PMC9630345. DOI:10.3389/ftox.2022.1010185.
  • McDonough CA, Li W, Bischel HN, De Silva AO, DeWitt JC. 2022. Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs). Environ Sci Technol. 56(10):6004-6013. [PMID: 35324171. PMCID: PMC] DOI:10.1021/acs.est.2c00254.
  • Roell K, Koval LE, Boyles R, Patlewicz G, Ring C, Rider CV, Ward-Caviness C, Reif DM, Jaspers I, Fry RC, Rager JE. 2022. Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research. Front Toxicol. 4:893924. PMID: 35812168. PMCID: PMC9257219. DOI: 10.3389/ftox.2022.893924.
  • Rosen EM, Kotlarz N, Knappe DRU, Lea CS, Collier DN, Richardson DB, Hoppin JA. 2022. Drinking Water–Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study. Environ Health Perspect. 130(9): 97002. PMID: 36969575. PMCID: PMC9450637. DOI: 10.129/EHP11033.
  • Starnes HM, Rock KD, Jackson TW, Belcher SM. 2022. A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior. Front Toxicol. 4:881584. PMID: 35480070. PMCID: PMC9035516. DOI: 10.3389/ftox.2022.881584. 
  • Truong L, Rericha Y, Thunga P, Marvel S, Wallis D, Simonich MT, Field JA, Cao D, Reif DM, Tanguay RL. 2022. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. J Hazard Mater. 431: 128615. PMID: 35263707. PMCID: PMD8970529. DOI: 10.1016/j.jhazmat.2022.128615. 
  • Wallis DJ, Barton KE, Knappe DRU, Kotlarz N, McDonough CA, Higgins CP, Hoppin JA, Adgate JL. 2022. Source apportionment of serum PFASs in two highly exposed communities. Sci Total Environ. 855:158842. PMID: 36122706. PMCID: PMC#. DOI:10.1016/j.scitotenv.2022.158842.
  • Witchey SK, Doyle MG, Fredenburg JD, Armour GS, Horman BM, Odenkirk MT, Aylor DL, Baker ES, Patisaul HB. 2022. Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters. Neuroendocrinology. PMID: 36075192. PMCID: PMC9992460. DOI: 10.1159/000526959. 

2021

  • Aly NA, Dodds J, Luo Y, Grimm FA, Foster MR, Rusyn I, Baker ES. 2021. Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites. Analytical and Bioanalytical Chemistry. 414(3):1245-1258. PMID: 34668045. PMCID: 8727508. DOI: 10.1007/s00216-021-03686-w.
  • Bilbao A, Gibbons BC, Stow SM, Kyle JE, Bloodsworth KJ, Payne SH, Smith RD, Ibrahim YM, Baker ES, Fjeldsted JC. 2021. A Preprocessing Tool for Enhanced Ion Mobility-Mass Spectrometry-Based Omics Workflows. J Proteome Res. 21(3): 798-807.  PMID: 34382401. PMCID: PMC8837709. DOI: 10.1021/acs.jproteome.1c00425.
  • Butler KE, Takinami Y, Rainczuk A, Baker ES, Roberts BR. 2021. Utilizing Ion Mobility-Mass Spectrometry to Investigate the Unfolding Pathway of Cu/Zn Superoxide Dismutase. Front Chem. 9:614595. PMID: 33634076. PMCID: PMC7900566. DOI: 10.3389/fchem.2021.614595.
  • Dodds JN, Alexander NLM, Kirkwood KI, Foster MR, Hopkins ZR, Knappe DRU, Baker ES. 2021. From Pesticides to Per- and Polyfluoroalkyl Substances: An Evaluation of Recent Targeted and Untargeted Mass Spectrometry Methods for Xenobiotics. Anal Chem. 93(1): 641-656. PMID: 33136371. PMCID: PMC7855838. DOI: 10.1021/acs.analchem.0c04359.
  • Dodds J, Baker ES. 2021. Improving the Speed and Selectivity of Newborn Screening Using Ion Mobility Spectrometry-Mass Spectrometry. Analytical Chemistry. 93(51):17094-17102. PMID: 34851605. PMCID: PMC8730783. DOI:10.1021/acs.analchem.1c04267. 
  • Enders JR, O’Neill GM, Whitten JL, Muddiman DC. 2021. Understanding the electrospray ionization response factors of per- and poly-fluoroalkyl substances (PFAS). Anal Bioanal Chem.414 (3):1227-1234. PMID: 34291300. PMCID: PMC8727445. DOI: 10.1007/s00216-021-03545-8.
  • Fleming J, Marvel S, Supak S, Motsinger-Reif A, Reif DM. 2021. ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS. J Expo Sci Environ Epidemiol. 32(6): 900-907. PMID: 35474345. PMCID: PMC9039976. DOI: 10.1038/s41370-022-00433-w.
  • Gilchrist PO, Alexander AB, Green AJ, Sanders FE, Hooker AQ, Reif DM. 2021. Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework. Education Sciences. 11(3): 109. PMID: 34824997. PMCID: PMC8612627. DOI: 10.3390/educsci11030109.
  • Jackson TW, Scheibly CM, Polera ME, Belcher SM. Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry. 2021. Environ Sci Technol. 55(18): 12291-12301. PMID: 34495656. PMCID: PMC8651256. DOI: 10.1021/acs.est.1c01200.
  • Khadempour L, Kyle JE, Webb-Robertson B, Nicora CD, Smith FB, Smith RD, Lipton MS, Currie CR, Baker ES, Burnum-Johnson KE. 2021. From Plants to Ants: Fungal Modification of Leaf Lipids for Nutrition and Communication in the Leaf-Cutter Ant Fungal Garden Ecosystem. mSystems. 6(2):e013070-20. PMID: 33758033. PMCID: PMC8547007. DOI: 10.1128/mSystems.01307-20.
  • Kirkwood KI, Christopher MW, Burgess JL, Littau S, Foster K, Richey K, Pratt BS, Shulman N, Tamura K, MacCoss MJ, MacLean BX, Baker ES. 2021. Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity. Journal of Proteome Research. 21(1): 232-242. PMID: 34874736. PMCID: PMC8741653. DOI:10.1021/acs.jproteome.1c00820.
  • Kirkwood KI, Fleming J, Nguyen H, Reif DM, Baker ES, Belcher SM. 2021. Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances. Environmental Science & Technology. 56(6): 3441-3451. PMID: 35175744. PMCID: PMC9199521. DOI: https://doi.org/10.1101/2021.08.24.457570.
  • Kofeler HC, Ahrends R, Baker ES, Ekroos K, Han X, Hoffmann N, Holcapek M, Wenk MR, Liebisch G. 2021. Recommendations for good practice in MS-based lipidomics. Journal of Lipid Research. 62: 100138. PMID: 34662536. PMCID: PMC8585648. DOI:10.1016/j.jlr.2021.100138.
  • Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. Environ Health Perspect.129 (1): 17701. PMID: 33400596. PMCID: PMC7785295. DOI: 10.1289/EHP8690.
  • Odenkirk MT, Reif DM, Baker ES. 2021. Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments. Anal Chem. 93(22): 7763-7773. PMID: 3402968. PMCID: PMC8465926. DOI: 10/1021/acs.analchem.0c04850.
  • Wallis DJ, Truong L, La Du J, Tanguay RL, Reif DM. 2021. Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. Toxics. 9(4): 77. PMCID: 33917455.PMC8067468. DOI: 10.3390/toxics9040077.
  • Zhang C, McElroy AC, Liberatore HK, Alexander NLM, Knappe DRU. 2021. Stability of Per- and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis. Environmental Science & Technology. 56(10): 6103-6112. PMID: 34734715. PMCID: PMC9065217. DOI: 10.1021/acs.est.1c03979.

2020

  • Cohen Hubal EA, Reif DM, Slover R, Mullikin A, Little JC. 2020. Children’s Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals. Int J Environ Res Public Health. 2020. 17(22): 8337. PMID: 33187264. PMCID: PMC7696947. DOI: 10.3390/ijerph17228337.
  • Dodds JN, Hopkins ZR, Knappe DRU, Baker ES. 2020. Rapid Characterization of Per- and Polyfluoroalkyl Substances (PFAS) by Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS). Analytical Chemistry. 92 (6):4427-4435. PMID: 32011866. PMCID: PMC7173758. DOI: 10.1021/acs.analchem.9b05364.
  • Gluge J, Scheringer M, Cousins IT, DeWitt JC, Goldenman G, Herzke D, Lohmann R, Ng CA, Trier X, Wang Z. 2020. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Environ Sci Process Impacts. 22(12): 2345-2373. PMID: 33125022. PMCID: PMC7784712. DOI: 10.1039/d0em00291g.
  • Kwiatkowski CF, Andrews DQ, Birnbaum LS, Bruton TA, DeWitt JC, Knappe DRU, Maffini MV, Miller MF, Pelch KE, Reade A, Soehl A, Trier X, Venier M, Wagner CC, Wang Z, Blum A. Scientific Basis for Managing PFAS as a Chemical Class. Environmental Science & Technology Letters. 7(8): 532–543. PMID: 34307722. PMCID: PMC8297807. DOI: 10.1021/acs.estlett/0c00255.
  • Odenkirk MT, Stratton KG, Gritsenko MA, Bramer LM, Webb-Robertson BM, Bloodsworth KJ, Weitz KK, Lipton AK, Monroe ME, Ash JR, Fourches D, Taylor BD, Burnum-Johnson KE, Baker ES. 2020. Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools. Mol Omics.16(6): 521-532. PMID: 32966491. PMCID: PMC7736332. DOI: 10.1039/d0mo00074d.
  • Odenkirk MT, Zin PPK, Ash JR, Reif DM, Fourches D, Baker ES. 2020. Structural-based connectivity and omic phenotype evaluations (SCOPE): A cheminformatics toolbox for investigating lipidomic changes in complex systems. Analyst. 145(22): 7197-7209. PMID: 33094747. PMCID: PMC7695036. DOI: 10.1039/d0an01638a.