Per- and polyfluoroalkyl substances (PFAS) are emerging as a major public health problem in North Carolina (NC) and across the US. PFAS comprise a class of almost 5,000 known compounds. Their unique chemical properties have been harnessed to make consumer and industrial products more water, stain, and grease resistant; they are found in products as diverse as cosmetics and firefighting foams. PFAS are resistant to degradation, move easily through the environment, and are suspected of accumulating in living organisms. Despite increasing evidence that they are found ubiquitously in the environment, there is a paucity of knowledge about their toxicity.
Our Center will address pressing questions about this class of compounds and will aim to advance understanding about PFAS environmental and human exposure in impacted areas of NC, toxicity and underlying mechanisms of thyroid and immune function, bioaccumulation potential, and remediation.